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August 7, 2025 6:42 View More Why Synthroid Isnt Working The Shocking Truth About T4, T3 & Thyroid Symptoms with McCall McPherson In this episode of Modern Thyroid Wellness, McCall McPherson unpacks one of the most common frustrations in thyroid care: why levothyroxine-based medications (like Synthroid) often leave patients feeling unwell, even when their labs look normal. Drawing from her own experience as a thyroid patient and her extensive clinical work, McCall explains the flawed assumption that every body seamlessly converts T4 into active T3and why thats simply not the case for many people

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Topical application (well-studied): Serums at 0.1-0.5%, creams at 0.2-1%, hair products at 0.1-0.3%

[DOI] [PubMed] [Google Scholar] 77.Jumpertz von Schwartzenberg R, et al